The Story of CD4⁺CD28⁻ T Cells Revisited: Solved or Still Ongoing?

Figure 1

Phenotypic and functional features of CD4⁺CD28⁻ T cells and their CD28⁺ counterparts (overview). Schematic representation of CD4⁺CD28⁺ (left half) and CD4⁺CD28⁻ (right half) T cells characterized by their specific surface marker and cytokines. Brackets on the sides describe the function, origin, or property of the receptors or cytokines. The size and the number of the displayed elements define their expression level.