Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast Cells

Figure 1

Gender and sex steroid concentration effect on histamine release in mast cells. Rat PMCs were treated with physiological (10 pM to 10 nM) and pharmacological concentrations (100 nM to 100 μM) of estradiol, progesterone, testosterone, and DHT for 30 min at 37°C. Values are means ± SEM of three independent experiments in triplicate. , , and female versus male at each hormone concentration. Comparisons between genders were performed by one-way analysis of variance (ANOVA), followed by Bonferroni’s multiple comparison test (GraphPad Prism). Basal histamine release was determined in nontreated PMC (no hormone treatment). Hormone concentration and gender had significant effect and the interaction is statistically significant ().

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