Activation-Inactivation Cycling of Rab35 and ARF6 Is Required for Phagocytosis of Zymosan in RAW264 Macrophages

Figure 1

Rab35 is recruited to the phagocytic cups. Live RAW264 macrophages expressing GFP-Rab35 were incubated with zymosan and were observed by confocal laser microscopy. Phase-contrast images are shown (upper panels). The elapsed time is indicated at the top. The binding of zymosan to the cell surface was set as time 0. The insets show higher-magnification images of the indicated regions of the cells. Scale bar: 5 μm.