CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?

Figure 2

The proposed signalling pathway of CD69. After binding a putative ligand (CD69L) that is most probably a membrane bound protein, the cytoplasmatic tail of CD69 associates with Jak3 kinase. Jak3 recruits and phosphorylates the transcription factor Stat5. Phosphorylated Stat5 (Stat5-P) dimerizes in the active form and translocates to the nucleus where it can regulate the gene transcription.