Journal of Immunology Research

Research Article

Local and Systemic IKK and NF-B Signaling Associated with Sjögren’s Syndrome Immunopathogenesis

Table 2

IKKα/β/γ/ε expression in the MSG from pSS patients and healthy controls by immunohistochemistry.


	Number	pIKKε	IKKε	pIKKα/β	IKKα/β	pIKKγ	pIκBα	IκBα	p-p65
	Number	Cytoplasm positive	Cytoplasm positive	Cytoplasm positive	Cytoplasm positive	Cytoplasm positive	Cytoplasm positive	Cytoplasm positive	Nuclear positive

Primary Sjögren syndrome	33	−: 0 +: 8 ++: 14 +++: 11 ++++: 0	−: 0 +: 4 ++: 8 +++: 15 ++++: 6	−: 33	−: 5 +: 6 ++: 5 +++: 14 ++++: 3	−: 33	−: 13 +: 5 ++: 7 +++: 8 ++++: 0	−: 0 +: 7 ++: 6 +++: 17 ++++: 3	−: 2 +: 16 ++: 15 +++: 0 ++++: 0

Healthy controls	26	−: 23 +: 3 ++: 0 +++: 0 ++++: 0	−: 6 +: 12 ++: 3 +++: 5 ++++: 0	−: 26	−: 4 +: 5 ++: 13 +++: 4 ++++: 0	−: 26	−: 22 +: 2 ++: 2 +++: 0 ++++: 0	−: 1 +: 4 ++: 8 +++: 12 ++++: 1	−: 26

The intensity of staining was evaluated semiquantitatively as follows: negative (−); weak, patchy (+); moderate, patchy [<50% of the cells] (++); moderate, diffuse [>50% of cells] (+++); strong, diffuse [>50% of cells] (++++).