Acceleration of Wound Healing by -gal Nanoparticles Interacting with the Natural Anti-Gal Antibody

Figure 6

Healing of excisional wounds in the skin of GT-KO pigs treated with α-gal nanoparticles or with saline and viewed on day 13. The original size of the wounds was  mm and 3 mm deep. The border of wounds was marked by tattooed dots to determine contraction during healing. Control wounds treated with saline display partial regeneration of the epidermis as a result of physiologic healing. However, wounds treated with 100 mg α-gal nanoparticles are almost completely or completely covered with regenerating epidermis. Wounds treated with 10 mg α-gal nanoparticles heal faster than saline treated wounds, however, somewhat slower than wounds treated with 100 mg α-gal nanoparticles in the same pig. There are no significant differences of wound contractions between saline treated and α-gal nanoparticles treated wounds. Modified from [21].