Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis

Figure 1

Quantification of MOG-specific B cell frequencies in MS patients and HI. Purified B cells, stained with CD19 antibody, were incubated with human albumin, rMOG, or tetanus toxin (TT) coated beads. After exclusion of dead cells (DAPI⁺), the frequency of B cells which recognized albumin or rMOG was obtained in MS patients () and HI () , unpaired -test. The frequency of B cells bound to TT coated beads was also assessed in MS patients () and in HI () (ns, , Mann-Whitney test).