Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis

Figure 7

Transmigration of B cells across brain vessel derived endothelial cells. (a) B cells were negatively selected and a transmigration assay across HCMEC/D3 cell line was performed. Transmigrated cells in MS () and HI () were counted; no difference was observed (ns, , Mann-Whitney test). (b) Transmigrated B cells were stained and incubated with MOG coated beads. The frequency of MOG-BBR was assessed in MS patients () and HI () (ns, , Mann-Whitney test).

(a)

(b)