Significant Depletion of CD4⁺ T Cells Occurs in the Oral Mucosa during Simian Immunodeficiency Virus Infection with the Infected CD4⁺ T Cell Reservoir Continuing to Persist in the Oral Mucosa during Antiretroviral Therapy

Figure 1

CD4⁺ T cells are a minor population of T cells in the oral mucosa of healthy animals. (a) The proportions of CD3⁺CD4⁺ and CD3⁺CD8⁺ T cells in peripheral blood and oral and rectal mucosa of healthy rhesus macaques. (b) The ratio of CD3⁺CD4⁺ : CD3⁺CD8⁺ T cells in peripheral blood and oral and rectal mucosa of healthy rhesus macaques.

(a)

(b)