Review Article

Computational Modelling Approaches on Epigenetic Factors in Neurodegenerative and Autoimmune Diseases and Their Mechanistic Analysis

Table 1

Role of microRNAs in PD epigenetics. 26 microRNAs have been identified that have been reported to control PD pathways. Positive and negative correlations of these microRNAs with PD mean if they are inducing or inhibiting the disease state, respectively. Also, we have enlisted the target genes for retrieved microRNAs.

Role of microRNAs in PD epigenetics
MicroRNA Relation to PDTarget

MIR133BNegative correlationPITX3
MIR1Negative correlationTPPP, BDNF
MIR29ANegative correlation
MIR221Negative correlation
MIR222Negative correlation
MIR223Negative correlation
MIR224Negative correlation
MIR30APositive correlationSLC6A3, FGF20, GRIN1, GRIA1
MIR16-2Positive correlationFGF20
Mir26a-2AssociatedGria1, Tyr
MIR886Positive correlation
MIR133BNegative correlation
MIR433Negative correlationFGF20
MIR7-1Negative correlation
MIR7-2Negative correlation
MIR-7Positive correlationSNCA
MIR34BPositive correlationPARK7, PARK2, TP53
MIR34CPositive correlationPARK7, PARK2, TP53
MIR219A1Negative correlationGRIN1, CD164
MIR219A2Negative correlationGRIN1, CD164
MIR124-1Positive correlationPPP1R13L
Mir219a-1Negative correlationGrin1
Mir219a-2Negative correlationGrin1
Mir124a-1Negative correlation
Mir124a-2Negative correlation
Mir124a-3Negative correlation