Research Article
EPIPOX: Immunoinformatic Characterization of the Shared T-Cell Epitome between Variola Virus and Related Pathogenic Orthopoxviruses
Table 4
Experimentally identified T-cell epitopes within the shared T-cell epitome predicted from pathogenic orthopoxvirus proteins.
(a) |
| CD8 T-cell epitopes | VARV GI | VARV ORF | Experimental HLA I restriction | Predicted HLA I restriction |
| ALMRRIAVV | 439013 | F5R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-A6802 | YLLSLFSTL | 439056 | A35L | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-A6802 | YLAKLTALV | 438985 | H5R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-A6802 | NLLCHIYSL | 438979 | K7L | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-Cw0702 | IVIEAIHTV | 439072 | J2R | HLA-A0201 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-Cw0304 | SLSAYIIRV | 439004 | I3L | HLA-A0201 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-A0207 | YLDGQLARL | 438965 | E6R | HLA-A0201 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-A0207 | YLPEVISTI | 438988 | H7L | HLA-A0201 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-Cw0102 | TYNDHIVNL | 439072 | J2R | HLA-A2301 | HLA-A2301 | HLA-A2402 | HLA-A2403 | HLA-A2405 | HLA-A2407 | HLA-Cw0702 | RPPSFYKPL | 439046 | A25R | HLA-B7 | HLA-B0702 | HLA-B3501 | HLA-B5101 | HLA-B5301 | HLA-B5401 | HLA-Cw0102 | ALDEKLFLI | 439045 | A24R | HLA-A0201 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-A0207 | FPYEGGKVF | 438968 | E9L | HLA-B0702 | HLA-B0702 | HLA-B1502 | HLA-B3501 | HLA-B5101 | HLA-B5301 | HLA-B5401 | RLYDYFTRV | 438973 | K1L | HLA-A0201, HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | | ILDDNLYKV | 438985 | H5R | HLA-A0201, HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0205 | HLA-A0207 | HLA-Cw0702 | | LLSYYVVYV | 439009 | F1R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | | FLIDLAFLI | 438960 | E1L | HLA-A2 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | HLA-Cw0304 | | FPRSMLSIF | 438994 | M4R | HLA-B07:02 | HLA-B0702 | HLA-B3501 | HLA-B4402 | HLA-B5301 | HLA-B5401 | | YLFDFVISL | 438996 | L1R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | | YLIKLIEPV | 439009 | F1R | HLA-A0201, HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | | SPSNHHILL | 439025 | A4L | HLA-B07:02 | HLA-B0702 | HLA-B3501 | HLA-B5101 | HLA-B5301 | HLA-B5401 | | YPSNKNYEI | 439033 | A12R | HLA-B07:02 | HLA-B0702 | HLA-B3501 | HLA-B5101 | HLA-B5301 | HLA-B5401 | | MLMETMFFI | 439007 | I6R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | | ILNPVASSL | 438998 | L3R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0205 | HLA-A0206 | HLA-B1501 | | FPSVFINPI | 438968 | E9L | HLA-B0702 | HLA-B0702 | HLA-B3501 | HLA-B5101 | HLA-B5301 | HLA-B5401 | | KYQSPVNIF | 439043 | A21R | HLA-A24, HLA-class I | HLA-A2301 | HLA-A2402 | HLA-A2403 | HLA-A2405 | HLA-A2407 | | YLFGGFSTL | 438980 | K8R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | | YLYETYHLI | 438981 | H1L | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0205 | HLA-A0206 | | | VLYNGVNYL | 439009 | F1R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0205 | HLA-A0206 | | | LIQEIVHEV | 439029 | A8L | HLA-A0201 | HLA-A0201 | HLA-A0202 | HLA-A0205 | HLA-A0206 | | | VELGSGNSF | 439043 | A21R | HLA-B3701 | HLA-B1501 | HLA-B1502 | HLA-B4402 | HLA-Cw0304 | | | RMIAISAKV | 438934 | P1L | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0206 | | | FILGIIITV | 439036 | A15L | HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0205 | HLA-A0206 | | | LLSKNTFYL | 438981 | H1L | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0205 | HLA-A0207 | | | RPRDAIRFL | 438961 | E2L | HLA-B0702 | HLA-B0702 | HLA-B3501 | HLA-B5301 | HLA-B5401 | | | KLFNKVPIV | 438996 | L1R | HLA-A2 | HLA-A0201 | HLA-A0202 | HLA-A0206 | HLA-A6802 | | | SLFMILCTR | 438979 | K7L | HLA-A0301, HLA-A1101 | HLA-A1101 | HLA-A3101 | HLA-A3301 | HLA-A6801 | | | ILNDEQLNL | 439029 | A8L | HLA-A0201 | HLA-A0201 | HLA-A0205 | HLA-A0207 | | | | YLLGDSDSV | 439038 | A17L | HLA-A2 | HLA-A0201 | HLA-A0205 | HLA-A0206 | | | | QLMYALEPR | 438985 | H5R | HLA-A0301, HLA-A1101 | HLA-A3101 | HLA-A3301 | HLA-A6801 | | | | LMDENTYAM | 439066 | A45R | HLA-A2 | HLA-A0205 | HLA-A0207 | HLA-Cw0702 | | | | GLLLGCFWV | 438955 | C17L | HLA-A2 | HLA-A0202 | HLA-A0203 | HLA-A0206 | | | | LLSHFYPAV | 438952 | C14L | HLA-A2 | HLA-A0201 | HLA-A0205 | HLA-A6802 | | | | NLFTFLHEI | 439045 | A24R | HLA-class I | HLA-A0201 | HLA-A0203 | HLA-A0206 | | | | GLFDFVNFV | 439070 | A49R | HLA-A2, HLA-A0201 | HLA-A0202 | HLA-A0203 | HLA-A0206 | | | | YLGPRVCWL | 439038 | A17L | HLA-A2 | HLA-A0202 | HLA-A0205 | HLA-A0206 | | | | ILKSLGFKV | 438980 | K8R | HLA-A2 | HLA-A0202 | HLA-A0203 | HLA-A0205 | | | | DEVASTHDW | 439025 | A4L | HLA-B4403 | HLA-B4402 | HLA-B5801 | | | | | FLVIAINAM | 439029 | A8L | HLA-A2, HLA-A0201 | HLA-A0206 | HLA-Cw0304 | | | | | LSDLKKTIY | 439040 | A19R | HLA-A1, HLA-class I | HLA-A0101 | HLA-B1501 | | | | | LLYFKVFGI | 439019 | N1L | HLA-A2 | HLA-A0202 | HLA-A0205 | | | | | SSNIMSESY | 439014 | F6R | HLA-A0101, HLA-A3002 | HLA-A0101 | HLA-B1501 | | | | | DTRGIFSAY | 439032 | A11L | HLA-A26, HLA-class I | HLA-A0101 | HLA-B5801 | | | | | QIDVEKKIV | 439029 | A8L | HLA-A0201 | HLA-A0207 | HLA-A6802 | | | | | YLFRCVDAV | 439030 | A9R | HLA-A2 | HLA-A0205 | HLA-A0206 | | | | | KIEDLINQL | 438973 | K1L | HLA-A0201 | HLA-A0203 | HLA-A0207 | | | | | FTIDFKLKY | 439009 | F1R | HLA-A1, HLA-A2601, HLA-A2902 | HLA-A0101 | HLA-Cw0702 | | | | | WLKIKRDYL | 439074 | J4R | HLA-B0801 | HLA-B0801 | | | | | | AINVEKIEL | 473688 | L6R | HLA-A0201 | HLA-A0207 | | | | | | RIFVRVYNV | 439007 | I6R | HLA-A2 | HLA-A0202 | | | | | | SIIDLIDEY | 438942 | C4R | HLA-B1501 | HLA-A0203 | | | | | | EERHIFLDY | 439009 | F1R | HLA-B4403 | HLA-B4402 | | | | | | ILSDENYLL | 439028 | A7L | HLA-A2, HLA-A0201 | HLA-A0205 | | | | | | HISALKRRY | 439027 | A6R | HLA-A0101, HLA-A2902 | HLA-A0101 | | | | | | FLNISWFYI | 438968 | E9L | HLA-A2, HLA-A02:01 | HLA-A0205 | | | | | | SEVKFKYVL | 439002 | I1L | HLA-B44 | HLA-B4402 | | | | | | KLLLWFNYL | 438980 | K8R | HLA-A2 | HLA-A0203 | | | | | | YIDISDVKV | 438973 | K1L | HLA-A0201 | HLA-A0207 | | | | | | VWINNSWKF | 439013 | F5R | HLA-A24, HLA-A2301, HLA-A2402 | HLA-Cw0702 | | | | | | VLPFDIKKL | 439014 | F6R | HLA-A0201 | HLA-Cw0102 | | | | | | VETSISDYY | 439043 | A21R | HLA-B3701 | HLA-B1501 | | | | | | SQIIDISLR | 439022 | A1L | HLA-A0301, HLA-A1101 | HLA-B2705 | | | | | | HDVYGVSNF | 439045 | A24R | HLA-B4403 | HLA-B4402 | | | | | |
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(b) |
| CD4 T-cell epitope | VARV GI | VARV ORF | Experimental HLA II restriction | Predicted HLA II restriction |
| FLIDLAFLI | 438960 | E1L | HLA-class II | DRB10101 | DRB10102 | DRB10301 | DRB10311 | DRB10401 | DRB11201 | DRB11302 | DRB11502 | DRB30101 | DRB50101 | IHWQIISSE | 439072 | J2R | DRB104:05 | DRB10405 | DRB10406 | DRB10410 | DRB11304 | DRB30101 | | | | | | YIDAYVSRL | 439021 | N3L | DRB115:01 | DRB10901 | DRB11103 | DRB30202 | | | | | | | | LMDENTYAM | 439066 | A45R | HLA-class II | DRB11103 | | | | | | | | | | IDAYVSRLL | 439021 | N3L | DRB115:01 | DRB11201 | | | | | | | | | | RMIAISAKV | 438934 | P1L | HLA-class II | DRB10407 | | | | | | | | | |
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T-cell epitopes in this table are a subset of those provided in Additional File S1.
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