Current Mathematical Models for Analyzing Anti-Malarial Antibody Data with an Eye to Malaria Elimination and Eradication

Figure 2

Analysis of seropositivity data. (a) Compartmental representation of the reversible catalytic model where individuals transit between seronegative and seropositive states with rates (SCR) and (SRR). (b) Compartmental representation of the superinfection model in which there are multiple seropositive states owing to immunity boosting upon recurrent malaria infections. (c) Analysis of seropositivity AMA1 data from northwest region of Bioko Island under the assumption of stable malaria transmission over time. (d) Similar data analysis for northeast region of Bioko Island. In plots (c) and (d), the dots represent the observed seroprevalence of distinct age groups by splitting the sampled age distribution into 7.5% centiles. To plot each seroprevalence, the median value of each age group was used.

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