|
| Gene/chromosome | Polymorphism | Population | Sample size (patients/controls) | value | Relative risk | Study/year |
|
| Interferon pathways |
| IRF5/Chr7 | rs2004640 | Caucasians | 364 (210/154) | 0.01 | 1.93 | Miceli-Richard et al. 2007 [51] |
rs10488631
CGGGG promoter insertion/deletion | Norwegian/Swedish | 1079 (368/711) | 2.4 10−5 | 1.49 | Nordmark et al. 2009 [52] |
| CGGGG promoter insertion/deletion | Caucasians | 824 (385/439) | 6 10−6 | 2.00 | Miceli-Richard et al. 2009 [53] |
| IRF5/TNPO3/Chr7 | rs13246321 | Norwegian/Swedish | 1072 (540/532) | 5.5 10−6 | 1.70 | Nordmark et al. 2011 [54] |
| rs3757387 | Caucasians | 10916 (4712/6204) | 2.73 10−19 | 1.44 | Lessard et al. 2013 [45] |
| STAT4/Chr2 | rs7574865 | Caucasians | 1232 (120/1112) | 0.01 | 1.47 | Korman et al. 2008 [55] |
| rs7582694 | Norwegian/Swedish | 1079 (368/711) | 0.0014 | 1.41 | Nordmark et al. 2009 [52] |
| rs7574865 | Colombian/German | 800 (277/523) | 7.7 10−6 | 1.40 | Palomino-Morales et al. 2010 [56] |
| rs7582694 | Norwegian/Swedish | 1072 (540/532) | 7 10−4 | 1.40 | Nordmark et al. 2011 [54] |
| rs10168266 | Chinese | 5622 (1845/3777) | 1.77 10−17 | 1.44 | Li et al. 2013 [46] |
rs10553577
rs13426947 | Caucasians | 10916 (4712/6204) | 6.8 10−15
9.45 10−9 | 1.43
1.32 | Lessard et al. 2013 [45] |
| IL12A/Chr3 | rs485497
rs583911 | Caucasians | 10916 (4712/6204) | 1.17 10−10
9.88 10−9 | 1.30
1.27 | Lessard et al. 2013 [45] |
| NCR3/NKp30/Chr6 | rs11575837 | French/Scandinavian | 1902 (1010/892) | 0.0039 | 0.48 |
Rusakiewicz et al. 2013 [57] |
| rs2736191 | | | 0.0019 | 0.56 |
| PTPN22/Chr1 |
rs2476601 | French | 3.55 (183/172) | ns | ns | Ittah et al. 2005 [58] |
| Colombian | 378 (70/308) | 0.01 | 2.42 | Gomez et al. 2005 [59] |
|
| B-cell function |
| BLK-FAM167A/Chr8 | rs12549796 | Norwegian/Swedish | 1072 (540/532) | 4.7 10−4 | 1.37 | Nordmark et al. 2011 [54] |
| rs7812879 | Chinese | 1152 (555/597) | 0.045 | — | Sun et al. 2013 [60] |
rs2736345
rs2729935
rs6998387 | Caucasians | 10916 (4712/6204) | 4.97 10−10
6.85 10−10
7.96 10−8 | 1.30
1.30
1.26 | Lessard et al. 2013 [45] |
| CXCR5/Chr11 | rs7119038
4936443 | Caucasians | 10916 (4712/6204) | 1.0 10−8
6.82 10−8 | 0.74
0.75 | Lessard et al. 2013 [45] |
| BAFF/Chr13 | −2841 T→C. −2704 T→C. −2701 T→A. −871 C→T | Caucasians | 259 (123/136) | <0.001 | — | Nossent et al. 2008 [61] |
rs1224141
rs12583006
rs9514828
rs1041569
rs9514827 | Greek | 330 (193/137) | <0.05 | — | Nezos et al 2014 [62] |
| GTF2I/chr7 | rs117026326 | Chinese | 5622 (1845/3777) | 1.31 10−53 | 2.20 | Li et al. 2013 [46] |
| EBF1/Chr5 | rs3843489 | Norwegian/Swedish |
1072 (540/532) | 9.9 10−5 | 1.68 | Nordmark et al. 2011 [54] |
| Ox40L-TNFSF4/Chr1 | rs1234315 | Norwegian/Swedish | 7.4 10−4 | 1.34 | Nordmark et al. 2011 [54] |
rs2205960
rs1234313 | Chinese | 643 (250/393) | <0.05 | — | Kong et al. 2013 [63] |
|
| NF-κB pathway |
| TNFAIP3/chr6 | rs2230926 | Caucasians | (18/397) | 0.038 | 3.38 | Musone et al. 2011 [64] |
| rs5029939 | Chinese | 5622 (1845/3777) | 7.75 10−5 | 1.67 | Li et al. 2013 [46] |
rs6933404
rs35926684 | Caucasians | 10916 (4712/6204) | 6.53 10−8
7.21 10−8 | 1.26
1.26 | Lessard et al. 2013 [45] |
| rs2230926 | Caucasians | 1025 (574/451) | 0.01 | 3.36 | Nocturne et al. 2013 [65] |
| TNIP1/Chr5 | rs6579837
rs7732451 | Caucasians | 10916 (4712/6204) | 3.30 10−8
5.32 10−7 | 1.43
1.34 | Lessard et al. 2013 [45] |
rs3792783
rs7708392 | Scandinavian/British | 5565 (1105/4460) | 3.4 10−5
1.3 10−3 | 1.33
1.21 | Nordmark et al. 2013 [66] |
| LTA/LTB/TNF gene clusters | rs1800629 | Norwegian/Swedish |
1060 (527/532) | 1.6 10−11 | — |
Bolstand et al. 2012 [67] |
| rs909253 | 4.42 10−8 | — |
| BAFF-R/Chr22 | Ηis159Tyr | Greek | 427 (247/180) | 0.01 | 2.75 | Papageorgiou et al. 2015 [68] |
|
