Review Article
Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases
Table 1
Major components of extracellular vesicles and their functions described.
| Origin | Molecule | Function | Reference |
| Tumor | MHC I and II | Antigen presentation | [18] | miRNA and mRNA | Oncogenic activity, drug resistance, and metastasis angiogenesis | [19–22] | CXCR4 and MMP-9 | Invasion and migration | [23] | TrkB, EGFR, and TES complex | Angiogenesis | [24] | Rab22A, Pabp1, and PSA | Metastasis | [25–27] | CD40, CD80, CD86, and CD54 | Immunity | [28] | GTPase and Rab27a | Upregulated immune system and inhibited tumor growth | [29] |
| Bacteria | OmpQ and pertactin | Immunogenic | [30] | Gene transfer | Communication | [31] | Gentamycin | Cell death | [32] | RNAs | Communication | [33, 34] |
| Protozoa | tGPI-mucin | Activation | [35] |
Tc85 | Invasion/adhesion | [36] | gp63 and LPG | Virulence factor | [37–39] | TS | Virulence factor | [40, 41] |
| Fungi | -gal | Immunogenic | [42] | GXM and GlcCer | Virulence factor | [43–45] |
| Eukaryotic mammalian cells | MHC I and II | Antigen presentation | [2] | FasL | Immune suppression | [13] |
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