Altered Traffic of Cardiolipin during Apoptosis: Exposure on the Cell Surface as a Trigger for “Antiphospholipid Antibodies”

Figure 1

Cardiolipin-mitochondria association following apoptotic triggering. T cells, untreated or treated with anti-CD95/Fas for 20 min, were stained with MCL-BODIPY, a green fluorescent analogue of CL [30, 31], and then with 50 nM Mitotracker red. Projected images from 33 z-sections of 0.2 nm, obtained after 10 cycles of deconvolution, were acquired by using a state-of-the-art Deltavision RT system.