Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients
Table 3
Distribution of CD4+ lymphocyte subpopulations in peripheral blood of pSS patients and controls.
Patients
1I-controls
2II-pSS Abs−
3III-pSS Abs+
I-II
I-III
II-III
CD4+ lymphocyte populations
CD4+CD25+
%4
10.00 ± 10.94
9.72 ± 6.1
11.64 ± 9.38
NS
NS
NS
A. count#
183.6 ± 222.3
132.7 ± 106.0
106.1 ± 75.89
NS
0.036
NS
CD4+CD25high
%4
1.97 ± 1.342
2.45 ± 1.71
2.71 ± 1.83
NS
NS
NS
A. count#
32.13 ± 25.88
31.81 ± 25.92
24.39 ± 13.50
NS
NS
NS
CD4+FoxP3
%4
4.56 ± 4.73
5.19 ± 6.69
5.012 ± 4.68
NS
NS
NS
A. count#
75.25 ± 82.62
59.45 ± 72.83
62.62 ± 105.0
NS
NS
NS
CD4+CD25+FoxP3
%4
1.12 ± 2.09
1.10 ± 0.90
0.90 ± 0.63
NS
NS
NS
A. count#
19.12 ± 42.33
13.19 ± 10.79
10.21 ± 13.65
NS
NS
NS
CD4+CD25highFoxP3
%4
0.27 ± 0.34
0.36 ± 0.31
0.35 ± 0.27
NS
NS
NS
A. count#
4.45 ± 6.9
4.039 ± 2.91
3.26 ± 2.81
NS
NS
NS
CD4+CD25lowFoxP3
%4
0.84 ± 1.75
0.78 ± 0.73
0.57 ± 0.51
NS
NS
NS
A. count#
14.57 ± 35.46
9.64 ± 9.612
6.71 ± 12.78
NS
0.017
NS
Th17
%4
2.08 ± 1.31
0.85 ± 1.08
1.51 ± 2.89
0.0003
0.004
NS
A. count#
34.44 ± 21.02
9.12 ± 10.89
10.89 ± 22.71
<0.0001
<0.0001
NS
I group: healthy controls; 2II group: pSS patients without anti-SSA/SSB; 3III group: pSS patients with anti-SSA and/or anti-SSB; %4: proportion of all CD4+ lymphocytes; A. count#: absolute count of cells in 1 μL of blood. *Mann-Whitney test. NS: not significant.