Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients

Table 4

Distribution of CD8⁺ lymphocyte subpopulations in peripheral blood of pSS patients and controls.

Patients	^1I-controls	^2II-pSS Abs^−	^3III-pSS Abs^+
				I-II	I-III	II-III
CD8^+ lymphocyte population
CD8^highCD57^+CD27^+
%^4	5.306 ± 3.899	5.329 ± 5.431	8.239 ± 8.239	NS	NS	0.032
A. count^#	34.26 ± 29.11	27.05 ± 33.57	42.59 ± 33.12	NS	NS	0.011
CD8^highCD57^+CD27^−
%^4	22.67 ± 13.33	25.52 ± 17.42	27.40 ± 19.55	NS	NS	NS
A. count^#	150.6 ± 119.7	143.4 ± 157.7	155.2 ± 136.8	NS	NS	NS
CD8^highCD57^−CD27^+
%^4	59.13 ± 17.54	46.51 ± 22.00	47.16 ± 22.29	0.026	NS	NS
A. count^#	387.3 ± 211.4	227.9 ± 186.6	224.8 ± 129.3	0.0003	0.005	NS
CD8^highCD57^−CD27^−
%^4	13.10 ± 8.112	22.60 ± 15.37	17.18 ± 11.20	0.024	NS	NS
A. count^#	85.79 ± 73.99	119.1 ± 126.7	99.46 ± 85.96	NS	NS	NS
CD8^+FoxP3
%^5	10.59 ± 15.16	5.881 ± 6.673	6.498 ± 7.939	NS	NS	NS
A. count^#	91.42 ± 126.1	51.19 ± 86.72	50.49 ± 60.37	NS	NS	NS

I group: healthy controls; ²II group: pSS patients without anti-SSA/SSB; ³III group: pSS patients with anti-SSA and/or anti-SSB; %⁴: proportion of all CD8^high lymphocytes; %⁵: proportion of all CD8⁺ lymphocytes. A. count^#: absolute count of cells in 1 μL of blood. ^*Mann-Whitney test. NS: not significant.