Research Article
Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides
Table 5
The mean values of all cell surface antigens according to clinical stage.
| | Clinical (T) stage | T1 | T2 | T3 | T4 | value | | 47 | 95 | 6 | 16 |
| | T cells surface antigens | | CD3+ | | | | | 0.000↑ | | Mean ± SD | 73.93 ± 7.07 | 71.31 ± 9.01 | 88.41 ± 8.67 | 77.25 ± 17.64 | | | Median; min.–max. | 74.50; 62.30–92.60 | 71.80; 48.70–96.50 | 87.70; 79.10–98.70 | 85.35; 43.60–93.20 | | | CD4+ | | | | | 0.000↑ | | Mean ± SD | 44.63 ± 9.42 | 44.49 ± 8.60 | 75.18 ± 19.31 | 60.27 ± 24.06 | | | Median; min.–max. | 44.70; 15.30–66.20 | 44.70; 20.60–63.90 | 74.35; 55.50–97.50 | 65.20; 15.80–92.30 | | | CD8+ | | | | | 0.005↓ | | Mean ± SD | 26.75 ± 10.56 | 24.12 ± 9.36 | 11.41 ± 10.32 | 14.23 ± 9.68 | | | Median; min.–max. | 23.20; 14.10–73.30 | 23.45; 9.40–66.30 | 11.60; 0.50–22.50 | 15.10; 1.50–32.60 | | | CD4+/CD8+ | | | | | 0.000↑ | | Mean ± SD | 2.7 ± 5.16 | 2.19 ± 1.21 | 51.10 ± 74.46 | 13.97 ± 20.21 | | | Median; min.–max. | 1.90; 0.20–35.30 | 1.80; 0.30–7.80 | 10.35; 2.50–183.20 | 3.90; 0.60–61.50 | | | TCRαβ+ | | | | | 0.000↑ | | Mean ± SD | 68.99 ± 7.42 | 66.68 ± 8.28 | 86.65 ± 9.48 | 71.68 ± 17.65 | | | Median; min.–max. | 68.60; 50.0–87.10 | 68.0; 45.80–86.0 | 86.3; 76.90–98.0 | 76.0; 42.0–93.70 | | | TCRγδ+ | | | | | 0.011↓ | | Mean ± SD | 5.19 ± 3.30 | 3.95 ± 2.63 | 1.66 ± 0.92 | 2.35 ± 2.66 | | | Median; min.–max. | 4.40; 0.80–13.60 | 3.25; 0.50–11.20 | 2.10; 0.40–2.60 | 1.45; 0.10–10.0 | | | CD7+ | | | | | 0.001↓ | | Mean ± SD | 77.89 ± 6.33 | 74.19 ± 11.33 | 79.63 ± 15.65 | 61.73 ± 21.63 | | | Median; min.–max. | 78.20; 58.60–93.10 | 76.10; 2.80–89.30 | 77.75; 54.70–98.0 | 66.50; 11.70–83.0 | | | CD4+CD7+ | | | | | 0.859↑ | | Mean ± SD | 38.91 ± 8.26 | 37.25 ± 8.41 | 64.85 ± 23.52 | 37.67 ± 17.19 | | | Median; min.–max. | 40.10; 13.40–53.10 | 37.05; 16.0–53.60 | 54.30; 42.50–96.50 | 35.45; 9.60–71.30 | | | CD4+CD7− | | | | | 0.002↑ | | Mean ± SD | 7.71 ± 7.75 | 7.81 ± 6.40 | 11.40 ± 16.17 | 24.02 ± 25.18 | | | Median; min.–max. | 5.70; 1.70–51.30 | 5.20; 1.0–35.90 | 4.65; 0.50–42.50 | 15.75; 2.30–88.90 | | | CD71+ | | | | | 0.002↑ | | Mean ± SD | 3.31 ± 2.78 | 4.79 ± 8.39 | 14.36 ± 15.71 | 17.45 ± 21.59 | | | Median; min.–max. | 2.50; 0.3–11.30 | 3.0; 0.10–71.0 | 7.80; 3.60–44.60 | 6.50; 1.4–57.70 | |
| | B cells surface antigens | | HLA-DR+ | | | | | 0.001↓ | | Mean ± SD | 29.46 ± 8.79 | 32.37 ± 9.11 | 21.56 ± 15.76 | 28.15 ± 15.30 | | | Median; min.–max. | 27.50; 19.60–56.40 | 31.10; 11.40–60.20 | 22.0; 3.80–43.70 | 25.60; 2.20–59.90 | | | CD19+ | | | | | 0.021↓ | | Mean ± SD | 11.37 ± 3.96 | 12.48 ± 4.89 | 8.13 ± 6.41 | 8.67 ± 4.37 | | | Median; min.–max. | 11.70; 1.50–19.10 | 11.95; 3.20–24.80 | 6.80; 1.0–15.70 | 8.50; 2.30–18.10 | | | HLA-DR+CD19+ | | | | | 0.030↓ | | Mean ± SD | 10.53 ± 3.92 | 11.64 ± 4.79 | 6.78 ± 7.17 | 7.72 ± 4.31 | | | Median; min.–max. | 10.60; 1.20–17.80 | 11.20; 2.90–24.70 | 4.75 ± 0.30–15.50 | 6.95; 0.40–17.40 | |
| | NKT cells surface antigens | | CD3+CD16+CD56+ | | | | | 0.006↓ | | Mean ± SD | 3.46 ± 3.10 | 3.57 ± 3.50 | 2.06 ± 2.12 | 1.50 ± 1.16 | | | Median; min.–max. | 2.50; 0.30–16.60 | 2.25; 0.20–20.50 | 1.60; 0.20–6.20 | 1.25; 0.20–3.80 | |
| | NK cells surface antigens | | CD3−CD16+CD56+ | | | | | 0.000↓ | | Mean ± SD | 13.28 ± 6.34 | 14.34 ± 8.30 | 2.90 ± 2.92 | 8.86 ± 9.84 | | | Median; min.–max. | 13.10; 2.60 | 13.60; 2.10–39.80 | 2.70; 0.10–8.0 | 3.30; 0.10–30.20 | |
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↓: decreasing with stage; ↑: increasing with stage.
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