Research Article
Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides
Table 6
ROC curve analysis of the investigated cell surface antigens to predict the cut-off value.
| | Cell surface antigen | Cut-off value criterion | Area under curve | value | Sensitivity (95% CI) | Specificity (95% CI) |
| | T cells surface antigens | | CD3+ | >79.1 | 0.859 | 0.001 | 87.50 (61.6–98.1) | 84.56 (22.5–55.2) | | CD4+ | >49.2 | 0.880 | 0.001 | 87.50 (61.6–98.1) | 84.56 (77.7–90.0) | | CD8+ | ≤5.2 | 0.835 | 0.001 | 62.5 (35.5–84.7) | 98.66 (95.2–99.8) | | CD4+/CD8+ | >2.4 | 0.873 | 0.001 | 93.75 (69.7–99.0) | 69.80 (61.70–77.0) | | TCRαβ+ | >73.1 | 0.887 | 0.001 | 92.86 (66.1–98.8) | 72.29 (71.6–85.7) | | TCRγδ+ | ≤2.4 | 0.847 | 0.001 | 85.71 (57.2–97.8) | 73.38 (65.2–80.5) | | CD7+ | ≤48 | 0.647 | 0.036 | 78.57 (49.2–95.1) | 50.74 (42.0–59.4) | | CD4+CD7+ | >47.8 | 0.680 | 0.028 | 50 (23.1–76.9) | 89.51 (83.3–94.0) | | CD4+CD7- | >9.4 | 0.660 | 0.053 | 64.29 (35.2–87.1) | 82.27 (74.9–88.2) | | CD71+ | >3.4 | 0.831 | 0.001 | 92.86 (66.1–98.8) | 63.43 (54.7–71.6) |
| | B cells surface antigens | | HLA-DR+ | ≤23.1 | 0.734 | 0.001 | 56.25 (26.9–80.2) | 97.3 (93.2–99.2) | | CD19+ | ≤6 | 0.691 | 0.001 | 43.75 (19.8–70.1) | 89.86 (83.8–94.2) | | HLA-DR+CD19+ | ≤5 | 0.723 | 0.001 | 56.25 (29.9–80.2) | 85.14 (78.4–90.4) |
| | NKT cells surface antigens | | CD3+CD16+CD56+ | ≤1 | 0.649 | 0.023 | 68.75 (41.4–88.9) | 62.16 (53.8–70.0) |
| | NK cells surface antigens | | CD3−CD16+CD56+ | ≤9.9 | 0.869 | 0.001 | 75.0 (47.6–92.6) | 92.52 (87.0–96.2) |
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