Research Article
Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus
Table 3
Genotype analysis of CREMα tagSNPs in SLE association, adjusting for sex and age.
| | SNPs | Genotype | Cases (%) | Controls (%) | Codominant | Dominant | Recessive | | OR (95% CI) | values | OR (95% CI) | values | OR (95% CI) | values |
| | rs1057108 | TT | 422 (48) | 417 (52) | 1.185 (0.999–1.405) | 0.052 | 1.200 (0.966–1.491) | 0.100 | 1.363 (0.916–2.028) | 0.127 | | TG | 372 (42) | 326 (41) | | GG | 85 (10) | 59 (7) |
| | rs2295415 | AA | 498 (62) | 497 (67) | 1.241 (1.009–1.527) | 0.041 | 1.222 (0.964–1.549) | 0.098 | 1.873 (0.967–3.625) | 0.063 | | AG | 279 (34) | 231 (31) | | GG | 32 (5) | 17 (2) |
| | rs11592925 | CC | 719 (82) | 654 (82) | 1.049 (0.813–1.354) | 0.712 | 1.055 (0.799–1.394) | 0.704 | 1.046 (0.369–2.964) | 0.933 | | CT | 153 (17) | 139 (17) | | TT | 8 (1) | 10 (1) |
| | rs1148247 | GG | 349 (43) | 307 (41) | 0.934 (0.794–1.10) | 0.416 | 0.916 (0.729–1.150) | 0.447 | 0.913 (0.657–1.629) | 0.588 | | GA | 356 (44) | 334 (45) | | AA | 109 (13) | 101 (14) |
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CREMα: cyclic AMP-responsive element modulator α; SNPs: single-nucleotide polymorphisms; SLE: systemic lupus erythematosus; OR: odds ratio; CI: confidence interval.
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