Vaccines for TB: Lessons from the Past Translating into Future Potentials

Table 1

Candidate vaccine with emerging protective responses and its brief description.

TB vaccine	Vaccine details
MVA85A [45]	Modified Vaccinia Ankara virus expressing Ag85A
VPM1002 [50]	rBCG expressing listeriolysin
AdAg85A [89]	Adenovirus expressing Ag85A
ΔIKEPLUS [90]	Mycobacterium smegmatis mutant that expresses M. tb esx-3 genes which is capable of inducing central memory responses
SO2 [52]	Mutant M. tb strain that has phoP deleted
Hybrid 1 + IC31 [91]	Fusion of ESAT-6 and Ag85B in adjuvant IC31
H4 [57]	Ag85B and TB10.4 administered with IC31 or DDA/MPL
H56 [58]	Ag85B and ESAT-6 administered with IC31
rBCG30 [92, 93]	30-kDa major secretory protein of Mycobacterium tuberculosis
M72 + AS01/AS02 [94]	Fusion protein of Rv1196 and Rv0125 in AS01 or AS02 adjuvant