Research Article
Peripheral Blood Mononuclear Cell Gene Expression Remains Broadly Altered Years after Successful Interferon-Based Hepatitis C Virus Treatment
Table 3
Genes with significantly different (
) downregulation in both SVR and NR when compared to SC.
| Gene ID | SC mean count | SVR mean count | NR mean count | Fold change SVR/SC | Fold change NR/SC | Fold change SVR/NR | value SC v SVR | value SC v NR | value SVR v NR |
| MAPK14 | 1896 | 1225 | 1292 | −1.6 | −1.5 | −1.1 | | | 0.273 | MAP3K7 | 899 | 606 | 602 | −1.5 | −1.5 | 1.0 | | | 0.943 | RPS6KA5 | 660 | 349 | 319 | −1.9 | −2.1 | 1.1 | | | 0.320 | CREB1 | 1070 | 711 | 701 | −1.5 | −1.5 | 1.0 | | | 0.749 | MAP2K6 | 333 | 216 | 227 | −1.5 | −1.5 | −1.1 | | | 0.402 | MAP3K5 | 676 | 470 | 479 | −1.4 | −1.4 | −1.0 | | | 0.586 | PPP1R12B | 156 | 75 | 87 | −2.1 | −1.8 | −1.2 | | | 0.125 | MYC | 1098 | 601 | 641 | −1.8 | −1.7 | −1.1 | | | 0.494 | PLCB1 | 382 | 216 | 239 | −1.8 | −1.6 | −1.1 | | | 0.311 | MAPKAPK5 | 963 | 654 | 644 | −1.5 | −1.5 | 1.0 | | | 0.708 | ROCK2 | 681 | 501 | 506 | −1.4 | −1.4 | −1.0 | | | 0.921 | HDAC4 | 372 | 272 | 284 | −1.4 | −1.3 | −1.0 | | | 0.476 |
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