Anti-Phosphatidylserine/Prothrombin Antibodies Are Associated with Adverse Pregnancy Outcomes
Table 4
Diagnostic accuracy of aPL for different adverse pregnancy outcomes.
≥3 consecutive miscarriages <10th WG
Fetal death >10th WG
Premature birth <34th WG
AUC
OR [95% CI]
AUC
OR [95% CI]
AUC
OR [95% CI]
LA
0.508
1.0 [1.0-1.1]
ns
0.563
1.1 [1.1-1.2]
0.001
/
/
/
aCL
0.516
2.8 [0.5–16.0]
ns
0.572
8.3 [1.8–37.6]
0.002
0.562
9.4 [1.8–49.6]
0.002
IgG
0.512
4.2 [0.4–41.6]
ns
0.558
12.6 [1.6–100]
0.003
0.568
19.1 [2.2–165]
<0.001
IgM
0.503
1.4 [0.1–22.2]
ns
0.52
4.2 [0.5–38.3]
ns
0.494
0.7 [0.7-0.8]
ns
anti-β2GPI
0.501
0.9 [0.2–3.3]
ns
0.497
0.8 [0.3–2.8]
ns
0.465
0.8 [0.2–4.5]
ns
IgG
0.492
0.7 [0.2–2.8]
ns
0.491
1.1 [0.4–3.6]
ns
0.465
0.9 [0.2–4.6]
ns
IgM
0.509
0.4 [0.4-0.5]
ns
0.513
0.5 [0.4–0.6]
ns
/
/
/
aPS/PT
0.534
5.3 [1.1–26.2]
0.026
0.559
6.8 [1.5–31.4]
0.005
0.544
7.5 [1.4–40.8]
0.008
IgG
0.531
9.0 [1.1–76.3]
0.017
0.533
7.5 [0.9–62.6]
0.030
0.550
15.2 [1.7–135]
0.002
IgM
0.512
4.3 [0.4–42.3]
ns
0.533
7.6 [0.9–63.3]
0.029
0.513
8.6 [0.9–85.9]
0.030
AUC: area under the curve, aCL: anticardiolipin antibody, anti-β2GPI: antibodies against β2-glycoprotein I, aPS/PT: anti-phosphatidylserine/prothrombin antibodies, CI: confidence interval, LA: lupus anticoagulant, ns: not significant, OR: odds ratio, and WG: week of gestation.
