Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population

Figure 2

Gene differential expression analyses of MICB in immune cell subsets and renal biopsies from SLE patients and controls. (a)–(h) present the MICB expression levels in immune cell subsets and renal biopsy samples from SLE patients and normal donor controls. MICB mRNA expression was significantly or marginally significantly upregulated in SLE B cells (489.80 ± 95.50 versus 352.66 ± 96.13; ; (b)), monocytes (1661.14 ± 532.87 versus 1065.38 ± 220.72; ; (e)), tubulointerstitial samples (4.33 ± 0.22 versus 4.21 ± 0.16; ; (g)), and glomeruli samples (7.92 ± 0.52 versus 6.77 ± 0.23; ; (h)). Although with a rather small sample size, a marginally significantly higher expression level of MICB has been observed in monocytes from healthy donors incubated with SLE sera compared to those incubated with autologous serum (1047.50 ± 494.43 versus 300.40 ± 48.88; ; (f)), while there was no difference of MICB mRNA expression in PBMC (1577.45 ± 488.74 versus 1610.67 ± 325.23; ; (a)), CD3+ T cells (2195.09 ± 865.77 versus 1900.54 ± 715.70; ; (c)), and CD4+ T cells (495.56 ± 144.59 versus 401.59 ± 94.80; ; (d)). PBMCs: peripheral blood mononuclear cells; SLE: systemic lupus erythematosus. The expression data of MICB was captured from ArrayExpress Archive database (http://www.ebi.ac.uk/arrayexpress/).

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