Preexisting Antibodies to an F(ab′)₂ Antibody Therapeutic and Novel Method for Immunogenicity Assessment

Table 1

Changes in titer by study day and by dose group.

Group	Change in titer	Number of animals/total number of animals
		Day 29	Day 57	Day 85	Day 112
Control	Decreased	0/10	0/10	0/4	0/4
	Unchanged	9/10	10/10	4/4	4/4
	Increased	1/10	0/10	0/4	0/4
5 mg/kg	Decreased	1/10	1/10	0/4	0/4
	Unchanged	2/10	2/10	1/4	1/4
	Increased	7/10	7/10	3/4	3/4
15 mg/kg	Decreased	5/10	3/10	0/4	0/4
	Unchanged	2/10	4/10	2/4	2/4
	Increased	3/10	3/10	2/4	2/4
50 mg/kg	Decreased	8/10	7/9	1/4	3/4
	Unchanged	1/10	1/9	2/4	0/4
	Increased	1/10	1/9	1/4	1/4