Prophylactic Chronic Zinc Administration Increases Neuroinflammation in a Hypoxia-Ischemia Model

Figure 3

Effect of prophylactic chronic administration of zinc and CCAO on chemokine expression profile in the temporoparietal cortex-hippocampus using RT² Profiler PCR array. CZn15 d, rats with chronic administration of zinc; Zn15 d+CCAO 8 h, rats with chronic administration of zinc before CCAO and evaluations at 8 h after reperfusion; Zn15 d+CCAO 7 d, rats with chronic administration of zinc before CCAO and evaluations at 7 days after reperfusion. Values show fold up- or downregulation as normalized with untreated control values. Each value represents the mean ± SEM of 3 independent experiments performed in triplicate. different from untreated rats (Student’s -test). The significance was established at .

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