Research Article
Clinical Associations of Biallelic and Monoallelic TNFRSF13B Variants in Italian Primary Antibody Deficiency Syndromes
Table 4
Frequencies of clinical complications in patients with wild-type and TACI-mutated CVID.
| | Wild-type
| TACI mutated
| value |
| Autoimmunity, (%) | 39 (23) | 10 (48) | 0.03 | Autoimmune cytopenia | 22 (13) | 9 (43) | 0.002 | Other autoimmune manifestations | 27 (16) | 3 (14) | ns | Lymphoproliferation, (%) | 101 (60) | 15 (71) | ns | Splenomegaly | 96 (57) | 14 (67) | ns | Lymphadenopathy | 41 (25) | 10 (48) | 0.03 | Granulomatous disease | 19 (11) | 6 (29%) | 0.04 | Malignant lymphoproliferation | 15 (19) | 1 (4%) | ns | Cancer, (%) | 27 (20) | 4 (17) | ns | Bronchiectasis, (%) | 72 (43) | 10 (53) | ns | Chronic diarrhea, (%) | 42 (25) | 5 (25) | ns |
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