Immune Regulation and Antitumor Effect of TIM-1

Figure 1

Tumor cells release signals, which are received by dendritic cells (DCs). Tumor antigens are processed to MHC antigens and then presented to the T cell receptor (TCR) for activation. TIM-4 (or phosphatidylserine) on DCs binds to TIM-1 on T cells to form the CD3-TCR complex, which participates in TCR-mediated T cell activation and initiates the intracellular PI3K signal pathway. PI3K signal pathway consists of the interaction between TIM-1 and ligands, tyrosine phosphorylation of the intracellular region of TIM-1, the recruitment of PI3K, the activation of Akt by PI3K, and the activation of mTOR by Akt. Activated mTOR can regulate the biological functions of T cells.