Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo

Figure 3

Effect of OPN variants on AICD of T cells. AICD was induced in PHA-derived T cell lines from healthy controls in the presence/absence of anti-CD3 and OPN variants. Results are expressed as relative cell survival % and are the mean ± SEM from 6 experiments. ( versus the control; Wilcoxon’s signed rank test).