The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis

Table 1

Gene ontology analysis of downregulated genes associated with glioma.

Category	Term/gene function	Count	%	value
GOTERM_MF_FAT	GO:0036094~small molecule binding	119	0.125	2.76E − 06
GOTERM_MF_FAT	GO:0000166~nucleotide binding	116	0.121	3.45E − 07
GOTERM_MF_FAT	GO:1901265~nucleoside phosphate binding	116	0.121	3.52E − 07
GOTERM_MF_FAT	GO:0097367~carbohydrate derivative binding	100	0.105	1.00E − 04
GOTERM_MF_FAT	GO:0019899~enzyme binding	94	0.098	2.24E − 07
GOTERM_MF_FAT	GO:0017076~purine nucleotide binding	92	0.096	9.44E − 06
GOTERM_MF_FAT	GO:0032555~purine ribonucleotide binding	91	0.095	1.26E − 05
GOTERM_MF_FAT	GO:0032553~ribonucleotide binding	91	0.095	1.76E − 05
GOTERM_BP_FAT	GO:0036211~protein modification process	148	0.155	8.31E − 04
GOTERM_BP_FAT	GO:0006464~cellular protein modification process	148	0.155	8.31E − 04
GOTERM_BP_FAT	GO:0023051~regulation of signaling	140	0.147	3.36E − 07
GOTERM_BP_FAT	GO:0010646~regulation of cell communication	139	0.146	2.25E − 07
GOTERM_BP_FAT	GO:0033036~macromolecule localization	138	0.145	5.25E − 09
GOTERM_BP_FAT	GO:0006793~phosphorus metabolic process	134	0.140	1.05E − 05
GOTERM_BP_FAT	GO:0006796~phosphate-containing compound metabolic process	133	0.139	1.53E − 05
GOTERM_BP_FAT	GO:0008104~protein localization	124	0.130	6.40E − 09
GOTERM_CC_FAT	GO:0005829~cytosol	163	0.171	4.20E − 08
GOTERM_CC_FAT	GO:0031988~membrane-bounded vesicle	152	0.159	2.84E − 04
GOTERM_CC_FAT	GO:0005654~nucleoplasm	130	0.136	2.88E − 04
GOTERM_CC_FAT	GO:0097458~neuron part	91	0.095	1.38E − 11
GOTERM_CC_FAT	GO:0030054~cell junction	75	0.078	1.15E − 05
GOTERM_CC_FAT	GO:0043005~neuron projection	66	0.069	1.72E − 08
GOTERM_CC_FAT	GO:0005794~Golgi apparatus	66	0.069	0.008029
GOTERM_CC_FAT	GO:0016023~cytoplasmic, membrane-bounded vesicle	64	0.067	7.15E − 05