Expansion. Highly suppressive CD39+ Treg subset increased in all disease stages
Increasingly suppressive regulatory function initiating at MBL stage; effector function impairment after transition to CLL; partially recovered after chemo-immunotherapy
Shorter time to treatment
Increased at diagnosis; significantly reduced after fludarabine therapy. CLL: chronic lymphocytic leukemia; MBL: monoclonal B cell lymphocytosis; PB: peripheral blood; FNA: fine needle aspiration; LDT: lymphocyte doubling time.