Journal of Immunology Research / 2017 / Article / Tab 4 / Review Article
Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies Table 4 Most relevant published studies investigating the frequency and the prognostic significance of Tregs in acute leukemias.
Reference Patients/controls evaluated Samples tested Marker panel used in Treg evaluation by flow cytometry Treg frequency Functional studies Impact on prognosis Bhattacharya et al. [58 ] B-ALL PBMC /BM CD4/CD25/CD127/FoxP3 Decreased Higher suppressive capability on CD4+ CD25− regulatory T cells than controls Increased frequency with disease progression Wu et al. [59 ] B-ALL/T-ALL/controls PB CD4/CD25 Higher Not performed Not evaluated Wang et al. [60 ] AML/controls PBMC /BM CD4/CD25 Higher Inhibition of proliferation and cytokine production (IL2, IFN-γ ) of CD4+ CD25− T cells; improved IL-10 production under coculture of both subsets with stimulation Not evaluated Idris et al. [61 ] B-ALL/controls PB and BM CD4/CD25/CD127 Increased Not performed Correlation with age
ALL: acute lymphoblastic leukemia; AML: acute myeloid leukemia; PB: peripheral blood; BM: bone marrow; PBMC: peripheral blood mononuclear cells; IL: interleukin; IFN: interferon.