Journal of Immunology Research

Research Article

The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA

Table 3

Comparison of the different mismatch characteristics between mismatches that led to the formation of DSA and ones that did not.
(a) HLA-DRB1 and DQA1/DQB1 mismatches
 No DSA DSA value
EpMS
 Antibody verified0.0714
 Others0.8993
PIRCHE-II0.0094
HMS0.1438
EMS0.3492
AMS0.1544
(b) HLA-DRB1 mismatches
 No DSA DSA value
EpMS0.0978
 Antibody verified0.1385
 Others0.1642
PIRCHE-II0.6275
HMS0.1516
EMS0.2155
AMS0.1919
(c) HLA-DQA1/DQB1 mismatches
 No DSA DSA value
EpMS0.3248
 Antibody verified0.2707
 Others0.6679
PIRCHE-II0.0836
HMS0.1993
EMS0.2105
AMS30.0524
Note. Values are expressed as mean ± SD; two-tailed values are shown.
AMS: amino acid mismatch score; DSA: donor-specific HLA antibody; EMS: electrostatic mismatch score; EpMS: eplet mismatch score; HMS: hydrophobicity mismatch score; PIRCHE-II: predicted indirectly recognizable HLA epitopes, HLA class II-presented.