Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury

Figure 2

eStat3^−/− and control mice were administered LPS (5 mg/kg i.p.) 4 hours prior to imaging and carboxy-DCFDA 20 minutes prior to imaging to assess tubular oxidative stress. (a) Representative images of carboxy-DCFDA fluorescence under the conditions as labeled. (b) The quantitative mean fluorescence for each condition (). Oxidative stress is significantly in greater degree in the eStat3^−/− mice following LPS administration as compared to control mice receiving LPS (⁺) or vehicle control ().

(a)

(b)