Glycomacropeptide Attenuates Inflammation, Pruritus, and Th2 Response Associated with Atopic Dermatitis Induced by 2,4-Dinitrochlorobenzene in Rat

Figure 1

Schematic diagram of experimental dermatitis induction protocol and GMP administration. Rats were sensitized on day 0 with injection of DNP-BSA mixed with Al(OH)₃ gel and simultaneously with B. pertussis vaccine. Animals were resensitized with topical application of DNCB in A-OO on days 14, 16, 18, 20, 22, and 36. Control group was injected with the adjuvants but without DNP-BSA and applied topically with A-OO mixture. GMP or water was administered, daily and orally, from 3 days before AD-induction or from day 23 after AD-induction, and until day 36 to analyze the prophylactic or therapeutic effect, respectively. Animals were sacrificed at day 37.