Research Article

Inflammatory Cytokine Pattern Is Sex-Dependent in Mouse Cutaneous Melanoma Experimental Model

Table 1

Cytokine/chemokine panel analyzed by Luminex-based cytokine bead array.

FunctionNameCell source

Proinflammatory cytokinesIL-1-beta, IFN-gammaLymphocytes
IL-12 (p70)Monocytes/macrophages and B cells
TNF-alphaMacrophages

Anti-inflammatory cytokinesIL-10Mainly monocytes

Pleiotropic cytokinesGM-CSFMacrophages, T cells, mast cells, natural killer cells, endothelial cells, and fibroblasts
IL-6Mainly T cells and macrophages

ChemokinesMCP-1Primarily monocytes, macrophages, and dendritic cells
MIP-1Memory CD8+ T cells
KCMacrophages, neutrophils, epithelial cells, and melanoma cells