Toll-Like Receptor Ligand-Induced Liver Injury in D-Galactosamine-Sensitized Mice: Differences between TLR7/8 and TLR9 Ligands, Cytokine Patterns, and Cross-Tolerance Induction by TLR2 Ligand Pretreatment

Table 2

Effect of CpG (20 μg), R848 (10 μg), and LTA (100 μg) in D-galN- (20 mg/mouse) sensitized mice. Mean ± SD is shown.

	Survival	ALT (U/l)	TNF-α (pg/ml)	IL-6 (pg/ml)
PBS ()
C57BL/6	All survived by 10 h	63.5 ± 14.5	3.2 ± 0.5	5.2 ± 1.8
C3H	All survived by 10 h	52.3 ± 10.8	2.1 ± 0.3	4.3 ± 2.8
CpG/D-galN ()
C57BL/6	Four of eight died within 10 h	18330.0 ± 5482.9	644.3 ± 187.7	1984.7 ± 771.4
C3H	Four of eight died within 10 h	267.7 ± 173.5	31.5 ± 43.6	105.2 ± 100.4
R848/D-galN ()
C57BL/6	All eight died within 9 h	12675.7 ± 6365.7	337.6 ± 140.3	1029.4 ± 927.3
C3H	All eight died within 9 h	5071.2 ± 2417.6	686.0 ± 406.7	1657.0 ± 813.2
LTA/D-galN ()
C57BL/6	All survived by 10 h	2536.7 ± 1346.0	63.0 ± 18.0	3208.0 ± 1046.3
C3H	All survived by 10 h	103.3 ± 35.6	8.2 ± 7.0	626.2 ± 290.9