Research Article
Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study
Table 4
Univariate analysis of variables associated with different fetal adverse maternal outcomes.
| | Characteristics | Fetal loss | Preterm birth | IUGR | Fetal distress | | Yes | No | | Yes | No | | Yes | No | | Yes | No | |
| | 12 | 231 | — | 54 | 189 | — | 36 | 207 | — | 27 | 216 | | | Disease flares during pregnancy | 11(91.7) | 41(17.7) | <0.001 | 27(50.0) | 25(13.2) | <0.001 | 16(44.4) | 36(17.4) | <0.001 | 9(33.3) | 43(19.9) | 0.1 | | Active lupus nephritis | 9(75.0) | 36(15.6) | <0.001 | 23(42.6) | 22(11.6) | <0.001 | 12(33.3) | 33(15.9) | 0.01 | 7(25.9) | 38(17.6) | 0.3 | | Thrombocytopenia | 5(41.7) | 18(7.8) | 0.002 | 8(14.8) | 15(7.9) | 0.1 | 4(11.1) | 19(9.2) | 0.8 | 5(18.5) | 18(8.3) | 0.2 | | Leukopenia | 2(16.7) | 5(2.2) | 0.04 | 2(3.7) | 5(2.6) | 0.7 | 0 | 7(3.4) | 0.3 | 1(3.7) | 6(2.8) | 0.6 | | PIH | 5(41.7) | 24(10.4) | 0.007 | 20(37.0) | 9(4.8) | <0.001 | 13(36.1) | 16(7.7) | <0.001 | 10(37.0) | 19(8.8) | <0.001 | | Anti-dsDNA antibody positivity | 5(41.7) | 88(38.1) | 0.8 | 21(38.9) | 72(38.1) | 1.0 | 16(44.4) | 77(37.2) | 0.4 | 9(33.3) | 84(38.9) | 0.6 | | Anti-Ro antibody positivity | 8(66.7) | 91(39.4) | 0.07 | 21(38.9) | 78(41.3) | 0.8 | 17(47.2) | 82(39.6) | 0.4 | 16(59.3) | 83(38.3) | 0.04 | | Anti-La antibody positivity | 2(16.7) | 31(13.4) | 0.7 | 8(14.8) | 25(13.2) | 0.8 | 5(13.9) | 28(13.5) | 1.0 | 3(11.1) | 30(13.9) | 0.7 | | LAC positivity | 5(41.7) | 14(6.1) | 0.001 | 8(14.8) | 11(5.8) | 0.03 | 4(11.1) | 15(7.2) | 0.4 | 4(14.8) | 15(6.9) | 0.2 | | Anticardiolipin antibody positivity | 8(66.7) | 21(9.1) | <0.001 | 15(27.8) | 14(7.4) | <0.001 | 7(25.9) | 22(10.2) | 0.03 | 9(25.0) | 20(9.7) | 0.02 | | Anti-beta2 GP1 positivity | 2(16.7) | 19(8.2) | 0.3 | 4(7.4) | 17(9.0) | 0.7 | 2(5.6) | 19(9.2) | 0.7 | 2(7.4) | 19(8.8) | 0.8 | | Hypoalbuminemia | 6(50.0) | 60(26.0) | 0.09 | 17(31.5) | 49(25.9) | 0.4 | 7(19.4) | 59(28.5) | 0.3 | 7(25.9) | 59(27.3) | 0.9 | | Hypocomplementemia | 9(75.0) | 47(20.3) | <0.001 | 17(31.5) | 39(20.6) | 0.1 | 10(27.8) | 46(22.2) | 0.3 | 6(22.2) | 50(23.1) | 0.9 | | Hydroxychloroquine | 9(75.0) | 117(50.6) | 0.1 | 29(53.7) | 97(51.3) | 0.8 | 16(44.4) | 46(22.2) | 0.3 | 11(40.7) | 115(53.) | 0.2 |
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