Research Article

CTLA4Ig Improves Murine iTreg Induction via TGFβ and Suppressor Function In Vitro

Figure 1

CTLA4Ig does not inhibit Treg proliferation in vitro. (a) Schematic illustration of Treg induction in vitro culture is shown. (b) Proliferation curve showing mean cell numbers for different culture conditions (all groups were stimulated with anti-CD3/CD28 in the presence of IL2) over time and (c) fold expansion after 144 h in culture are shown. Cells were plated in quadruplicates; control indicates CD4 T cells stimulated with anti-CD3/CD28 in the presence of IL2; results are representative for 3 independent experiments. Error bars represent standard deviation. , , and .
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