CTLA4Ig Improves Murine iTreg Induction via TGF<i>β</i> and Suppressor Function <i>In Vitro</i>

<div>CTLA4Ig enhances the proportion of induced Tregs <i>in vitro.</i> (a) Representative histograms of Treg markers are shown for different culture conditions (gated on total leucocytes). CD4<sup>+</sup>CD25<sup>+</sup> T cells were analyzed (b) for the expression of FoxP3 (indicating induction of regulatory phenotype) by intracellular FACS staining after 6 days of in vitro culture ± CTLA4Ig and (c) Treg-associated markers CTLA4 and CD62L, which were analyzed and compared between groups. Cells were plated in triplicates for each culture condition. Data are representative for 3 independent experiments; control indicates CD4 T cells stimulated with anti-CD3/CD28 in the presence of IL2. 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Journal of Immunology Research

fig2

Figure 2

Figure 2: CTLA4Ig Improves Murine iTreg Induction via TGF<i>β</i> and Suppressor Function <i>In Vitro</i> 

Journal of Immunology Research

CTLA4Ig Improves Murine iTreg Induction via TGFβ and Suppressor Function In Vitro

Figure 2