CTLA4Ig Improves Murine iTreg Induction via TGF<i>β</i> and Suppressor Function <i>In Vitro</i>

<div>The presence of CTLA4Ig does not interfere with cytokine release <i>in vitro.</i> Supernatant of in vitro Treg induction cultures was collected at different time points and analyzed for the change in cytokine expression. (a) CD4<sup>+</sup> T cell cultures cultivated in the presence of TGF<i>β</i> showed significant increase in the production of suppressive cytokine IL-10 and (b) a significant decrease in the production of inflammatory cytokine IL-17A. Data were obtained from cells cultivated in triplicates and are representative for 3 independent experiments; control indicates CD4 T cells stimulated with anti-CD3/CD28 in the presence of IL2. 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Journal of Immunology Research

fig4

Figure 4

Figure 4: CTLA4Ig Improves Murine iTreg Induction via TGF<i>β</i> and Suppressor Function <i>In Vitro</i> 

Journal of Immunology Research

CTLA4Ig Improves Murine iTreg Induction via TGFβ and Suppressor Function In Vitro

Figure 4