Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept”

Figure 2

Pfizer’s analysis of one representative batch of Infinitam by UPLC versus Enbrel reference standard. Note: All major glycans observed in Enbrel were identified in each of the three batches of Infinitam drug product. The overall abundance of grouped neutral (peaks 1–5) and sialylated (peaks 6–9) species was outside the commercial experience of Enbrel. Infinitam would not be regarded as comparable to Enbrel due to the presence of two glycan species in each batch of Infinitam which are not resolved in Enbrel (arrows show baseline for Enbrel).