The Beneficial Effect of Human Amnion Mesenchymal Cells in Inhibition of Inflammation and Induction of Neuronal Repair in EAE Mice

Figure 3

hAMC suppresses the production of proinflammatory cytokines in EAE mice. (a–d) Effect of hAMC on the production of cytokines in the serum. The levels of TNF-α, IFN-γ, IL-1β, and IL-17A in the serum of mice were determined by ELISA. (e–h) Effect of hAMC on the mRNA levels of cytokines. The mRNA levels of TNF-α, IFN-γ, IL-1β, and IL-17A in the spinal cords of mice were detected by real-time PCR. Data were mean ± SD. mice per group. , compared to normal group. , , compared to model group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)