The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response

Figure 1

The expression of PKC isoforms in macrophages and their role in TLR-mediated inflammatory response. Among them eight, PKC isoforms (PKCα, βI, βII, δ, ε, η, ζ, and λ) are expressed in macrophages. PKCα, δ, ε, and ζ are directly related to TLR-induced inflammatory response. PKCθ expression in macrophages cannot be detected, but its expression can be induced by LPS/IFNγ stimulation.