Expression of PD-1 on CD4⁺ Tumor-Infiltrating Lymphocytes in Tumor Microenvironment Associated with Pathological Characteristics of Breast Cancer

Table 2

The relationship between CD4/PD-1 TILs and clinical characteristics.

	CD4^+TILs		CD4^+/PD1^+TILs		CD4^+/PD1^−TILs
Age, median (IQR)^∗		0.024		0.069		0.045
≤55	56 (67)		17 (38)		32 (43)
>55	40 (54)		13 (22)		25 (29)
Histological grade, median (IQR)^∗∗		0.083		0.136		0.092
I	40 (48)		13 (29)		17 (26)
II	45 (65)		13 (32)		32 (33)
III	55 (82)		22 (40)		32 (58)
Vascular invasion, median (IQR)		0.316		0.914		0.275
No	42 (63)		15 (32)		26 (35)
Yes	54 (47)		16 (25)		32 (22)
Nerve invasion, median (IQR)^∗		0.601		0.826		0.365
No	44 (48)		16 (28)		27 (28)
Yes	54 (88)		14 (44)		32 (53)
Axillary lymph node metastasis, median (IQR)^∗		0.469		0.725		0.169
No	67 (71)		20 (26)		50 (47)
Yes	57 (48)		14 (45)		30 (33)

^∗Wilcoxon test. ^∗∗Spearman correlation test.