An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity

Table 2

Genetic association with pathogenetic pathways in immediate-type drug hypersensitivity.

Associated drug	Ethnicity	Cytokines/chemokines	Production and release of mediators	Drug metabolism	Others	Reference
Beta-lactam antibiotics	Korean	—	MS4A2	—	—	[247, 248]
	Chinese	IL4R, IL4, IL10, IL13, IFNGR1, STAT6	—	—	—	[69, 70, 249–252]
	Italian	IL4R, IL13, NOD2	LGALS3	—	—	[66, 68, 73]
	French	IL4R, IL10	—	—	—	[253]
	American	IL4R, IL4	—	LACTB	—	[67]
	Spanish	IL4R, TNF, NOD2	LGALS3	—	—	[66, 73, 254, 255]
Aspirin	Korean	IL18, TGFB1, TNF	ALOX5, FCER1A, FCER1G, HNMT, TBXA2R, PTGER4	—	—	[76, 256–263]
	Poles	—	LTC4S	—	GSTM1	[264]
	Venezuelan	—	LTC4S	—	—	[265]
NSAIDs	Spanish	—	ALOX5, ALOX5AP, ALOX15, CTSLTR1, DAO, PPARG, PTGDR, TBXAS1	—	CEP68	[78, 266, 267]
	French	—	ALOX5, PTGER1	—	—	[268]
	Brazilian	IL4R, IL10	DAO	—	CTLA4	[269]