TNFAIP3 F127C Coding Variation in Greek Primary Sjogren’s Syndrome Patients

Figure 1

Prevalence of the rs2230926G single-nucleotide polymorphism in primary Sjogren’s syndrome (SS) patients and healthy controls (HC). (a) Increased frequency of the rs2230926G variant was detected in all SS study participants compared to HC (26 out of 327 (8.0%) vs. 16 out of 448 (3.6%), value: 0.01, by Fisher’s exact test). (b) Both SS-non lymphoma and SS-lymphoma patients displayed higher rates of the rs2230926 compared to HC (18 out of 236 (7.7%) and 8 out of 91 (8.8%) vs. 16 out of 448 (3.6%), values: 0.03 and 0.04, respectively, by Fisher’s exact test). (c) When SS subsets were stratified according to the age of SS onset, only the younger-onset (≤40 years) subgroup complicated by lymphoma exhibited significantly higher frequencies of the rs2230926G variant compared to HC (4 out of 22 (18.2%) vs. 16 out of 448 (3.6%), , by Fisher’s exact test).

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