Expression of Gαq Is Decreased in Lymphocytes from Primary Sjögren’s Syndrome Patients and Related to Increased IL-17A Expression

Table 1

Demographic and clinical characteristics of pSS patients.

	pSS	Health controls
Number,	39	40	NS
Age (years), mean ± SD	46.1 ± 8	48 ± 9	NS
Sex, M/F	3/36	4/36	NS
Disease duration (years), mean ± SD	2.7 ± 1.2
Clinical manifestations, (%)
Oral dry	27 (69)	0 (0)
Eye dry	24 (62)	0 (0)
Arthritis	14 (36)	0 (0)
Pulmonary domain	12 (31)	0 (0)
Autoimmune hemolytic anemia	13 (43)	0 (0)
Lymphopenia	5 (13)	0 (0)
Renal involvement	12 (31)	0 (0)
Nervous system involvement	2 (5)	0 (0)
ESSDAI score, mean (range)	3 (0–10)
Active disease (ESSDAI ≥ 4)	9
Serological features, (%)
ANA	31 (79)	0 (0)
Anti-SSA/Ro	33 (85)	0 (0)
Anti-SSB/La	21 (54)	0 (0)
Anti-SSA/Ro and anti-SSB/La	20 (51)	0 (0)
Low serum C3	19 (49)	0 (0)
High serum IgG	16 (41)	0 (0)
CRP	22 (56)	0 (0)
ESR	27 (69)	0 (0)