Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice

Figure 2

Lung histopathological analysis in LPF-infected A/J mice. Mice were inoculated i/p with LPF or only PBS and then euthanized on the third or the sixth days postinfection (). (a) Lung sections (3–5 μm) were stained with HE and evaluated at 200x magnification. The inserts present the immunohistochemical analysis of the lung from LPF-infected mice evaluated at 400x magnification. (b) Total scores of lung lesions. A/J^-/-: C5-deficient mice, PBS (), 3 dpi (), 6 dpi (); A/J C5^+/+: congenic C5-sufficient mice PBS (), 3 dpi (), 6 dpi ().dpi: days postinfection.

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