Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice

Table 1

Physiological profile of A/J mouse strain infected by LPF.

		A/J C5^+/+			A/J C5^-/-
	PBS (n = 5)	3 dpi ()	6 dpi ()	PBS ()	3 dpi ()	6 dpi ()
Weight gain; (%)		^a	^a			^bc
Splenomegaly; (%)		^a	^a		^a	^a
Circulating leukocytes; (10^6 cells/ml)			^b
ALT; (U/dl)		^a	^b			^b
AST; (U/dl)		^a	^b
Urea; (mg/dl)		^a	^b		^a	^a
Uric acid; (mg/dl)

Notes: the body weight was recorded immediately before the infection and at the end of the experiment. The spleen weight was normalized by the body weight at the end of the experiment. Abbreviations: A/J C5^+/+ (A/J C5-sufficient mice), A/J C5^-/- (A/J C5-deficient mice); dpi: days postinfection. Statistical representation: a vs. PBS; b vs. 3 dpi; c vs. A/J C5^+/+. All data are presented as mean and standard error.